Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in oligodendrocyte progenitor cells (77 nCPM) | 1.00 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4562
Sealed predictions
- LRRC4B in dopamine neurons, braak+0.00 (p 1.000) → -0.06 (p 0.888)receipt 4570
- LRRC4B in oligodendrocytes, braak-0.82 (p 0.007) → -0.54 (p 0.137)receipt 4569
Swarm cases
receipt 4570: LRRC4B in dopamine neurons, braak
- power
- full sample -0.03 (p 0.908, n 18), 95% CI -0.49 to +0.44. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.03 (p 0.908, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.03 (p 0.915, n 18). could be the mix.
- skeptic
- leave-one-out range -0.19 to +0.07, sign flips 6; without severely affected donors -0.03 (p 0.908, n 18). fragile.
- cell type
- strongest in oligodendrocytes: -0.63 (p 0.0053, n 18) vs -0.03 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LRRC4B in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up LRRC4B · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.78 p 0.0059 (needs p < 4.4e-4)
receipt 4569: LRRC4B in oligodendrocytes, braak
- power
- full sample -0.63 (p 0.0053, n 18), 95% CI -0.85 to -0.23. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.63 (p 0.0053, n 18). holds up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.59 (p 0.011, n 18). not the mix.
- skeptic
- leave-one-out range -0.72 to -0.57, sign flips 0; without severely affected donors -0.63 (p 0.0053, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LRRC4B in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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