Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 15 Parkinson's papers of 336 | 0.64 |
| pathways Reactome | 2 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 7191
Sealed predictions
- LRPPRC in dopamine neurons, braak+0.41 (p 0.277) → +0.30 (p 0.441)receipt 7197
Swarm cases
receipt 7197: LRPPRC in dopamine neurons, braak
- power
- full sample +0.37 (p 0.130, n 18), 95% CI -0.12 to +0.71. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.36 (p 0.145, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.38 (p 0.116, n 18). could be the mix.
- skeptic
- leave-one-out range +0.28 to +0.54, sign flips 0; without severely affected donors +0.37 (p 0.130, n 18). fragile.
- cell type
- strongest in OPCs: +0.70 (p 0.0011, n 18) vs +0.37 in dopamine neurons. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LRPPRC in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up LRPPRC · OPCs · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.52 p 0.062 (needs p < 2.9e-4)
Receipts
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