Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in pituicytes/fscs | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 543 | 0.85 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 10006
Sealed predictions
- LRP4 in oligodendrocytes, braak-0.16 (p 0.680) → -0.22 (p 0.569)receipt 10014
- LRP4 in dopamine neurons, braak+0.05 (p 0.891) → -0.02 (p 0.964)receipt 10015
Swarm cases
receipt 10015: LRP4 in dopamine neurons, braak
- power
- full sample +0.00 (p 0.990, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.00 (p 0.997, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.01 (p 0.969, n 18). could be the mix.
- skeptic
- leave-one-out range -0.13 to +0.09, sign flips 6; without severely affected donors +0.00 (p 0.990, n 18). fragile.
- cell type
- strongest in astrocytes: +0.60 (p 0.0089, n 18) vs +0.00 in dopamine neurons. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LRP4 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up LRP4 · astrocytes · braak: substantia nigra, an independent cohort (already registered)
receipt 10014: LRP4 in oligodendrocytes, braak
- power
- full sample -0.26 (p 0.302, n 18), 95% CI -0.65 to +0.24. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.15 (p 0.544, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.10 (p 0.690, n 18). could be the mix.
- skeptic
- leave-one-out range -0.45 to -0.19, sign flips 0; without severely affected donors -0.26 (p 0.302, n 18). fragile.
- cell type
- strongest in astrocytes: +0.60 (p 0.0089, n 18) vs -0.26 in oligodendrocytes. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LRP4 in oligodendrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up LRP4 · astrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.02 p 0.929 (needs p < 2.2e-4)
Receipts
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