Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.09 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 36 Parkinson's papers of 75 | 0.53 |
| pathways Reactome | 1 pathway; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 2849
Sealed predictions
- LRP10 in dopamine neurons, braak-0.47 (p 0.201) → -0.13 (p 0.738)receipt 2856
Swarm cases
receipt 2856: LRP10 in dopamine neurons, braak
- power
- full sample -0.46 (p 0.056, n 18), 95% CI -0.76 to +0.01. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.43 (p 0.074, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.43 (p 0.079, n 18). could be the mix.
- skeptic
- leave-one-out range -0.54 to -0.39, sign flips 0; without severely affected donors -0.46 (p 0.056, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LRP10 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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