Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | enriched in the midbrain (6 nTPM), where the nigral dopamine neurons sit | 0.90 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 585 Parkinson's trials, 3 stopped | 0.95 |
| literature PubMed | 111 Parkinson's papers of 8,122 | 0.38 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6955
Sealed predictions
- LPO in dopamine neurons, braak-0.11 (p 0.778) → -0.26 (p 0.500)receipt 6962
Swarm cases
receipt 6962: LPO in dopamine neurons, braak
- power
- full sample -0.20 (p 0.418, n 18), 95% CI -0.61 to +0.29. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.23 (p 0.351, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.29 (p 0.246, n 18). could be the mix.
- skeptic
- leave-one-out range -0.33 to -0.11, sign flips 0; without severely affected donors -0.20 (p 0.418, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LPO in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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