Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 22 Parkinson's trials, 3 stopped | 0.89 |
| literature PubMed | 10 Parkinson's papers of 8,473 | 0.69 |
| pathways Reactome | 5 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 4083
Sealed predictions
- LPL in dopamine neurons, braak+0.92 (p 4.0e-4) → -0.26 (p 0.493)receipt 4091
Swarm cases
receipt 4091: LPL in dopamine neurons, braak
- power
- full sample +0.46 (p 0.054, n 18), 95% CI -0.01 to +0.76. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.47 (p 0.049, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.47 (p 0.047, n 18). not the mix.
- skeptic
- leave-one-out range +0.39 to +0.58, sign flips 0; without severely affected donors +0.46 (p 0.054, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LPL in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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