parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	group enriched in microglia (73 nCPM)	1.00
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 252	0.85
pathways Reactome	1 pathway; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 8968

LILRB1 in dopamine neurons, braak-0.73 (p 0.025) → -0.18 (p 0.648)receipt 8976
LILRB1 in microglia, braak+0.14 (p 0.724) → -0.20 (p 0.597)receipt 8975

receipt 8976: LILRB1 in dopamine neurons, braak

power: full sample -0.57 (p 0.014, n 18), 95% CI -0.82 to -0.14. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: -0.58 (p 0.013, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.58 (p 0.013, n 18). not the mix.
skeptic: leave-one-out range -0.65 to -0.53, sign flips 0; without severely affected donors -0.57 (p 0.014, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LILRB1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 8975: LILRB1 in microglia, braak

power: full sample +0.01 (p 0.976, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.04 (p 0.867, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.03 (p 0.915, n 18). could be the mix.
skeptic: leave-one-out range -0.13 to +0.15, sign flips 6; without severely affected donors +0.01 (p 0.976, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LILRB1 in microglia.

case closed: nothing better to follow up.

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