parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.05 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in choroid plexus epithelial cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	23 Parkinson's papers of 1,289	0.58
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 5024

receipt 5032: LGI1 in dopamine neurons, braak

power: full sample +0.48 (p 0.044, n 18), 95% CI +0.02 to +0.77. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: +0.52 (p 0.028, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.43 (p 0.077, n 18). could be the mix.
skeptic: leave-one-out range +0.41 to +0.59, sign flips 0; without severely affected donors +0.48 (p 0.044, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LGI1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 5031: LGI1 in astrocytes, braak

power: full sample -0.47 (p 0.051, n 18), 95% CI -0.77 to +0.00. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.50 (p 0.033, n 18). holds up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.44 (p 0.066, n 18). could be the mix.
skeptic: leave-one-out range -0.57 to -0.40, sign flips 0; without severely affected donors -0.47 (p 0.051, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LGI1 in astrocytes.

case closed: nothing better to follow up.

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