Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.10 (overall 0.06) | 0.10 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 78 | 0.85 |
| pathways Reactome | 10 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 4450
Sealed predictions
- KPNA1 in dopamine neurons, braak-0.12 (p 0.768) → +0.45 (p 0.230)receipt 4457
Swarm cases
receipt 4457: KPNA1 in dopamine neurons, braak
- power
- full sample +0.15 (p 0.549, n 18), 95% CI -0.34 to +0.58. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.17 (p 0.498, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.31 (p 0.218, n 18). could be the mix.
- skeptic
- leave-one-out range +0.05 to +0.29, sign flips 0; without severely affected donors +0.15 (p 0.549, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for KPNA1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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