Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (esophageal apical cells) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 11 Parkinson's papers of 315 | 0.67 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 5021
Sealed predictions
- KLK6 in dopamine neurons, braak+0.34 (p 0.373) → +0.11 (p 0.773)receipt 5027
Swarm cases
receipt 5027: KLK6 in dopamine neurons, braak
- power
- full sample +0.24 (p 0.337, n 18), 95% CI -0.26 to +0.64. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.31 (p 0.214, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.34 (p 0.161, n 18). could be the mix.
- skeptic
- leave-one-out range +0.14 to +0.42, sign flips 0; without severely affected donors +0.24 (p 0.337, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for KLK6 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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