Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 29 Parkinson's trials, 2 stopped | 0.94 |
| literature PubMed | 15 Parkinson's papers of 8,292 | 0.64 |
| pathways Reactome | 12 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 5414
Sealed predictions
- KL in dopamine neurons, braak-0.01 (p 0.982) → +0.20 (p 0.613)receipt 5422
Swarm cases
receipt 5422: KL in dopamine neurons, braak
- power
- full sample +0.07 (p 0.794, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.05 (p 0.847, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.03 (p 0.915, n 18). could be the mix.
- skeptic
- leave-one-out range -0.04 to +0.20, sign flips 4; without severely affected donors +0.07 (p 0.794, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for KL in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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