Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in astrocytes (479 nCPM) | 1.00 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 177 | 0.85 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8247
Sealed predictions
- KCNN3 in dopamine neurons, braak-0.55 (p 0.125) → -0.26 (p 0.500)receipt 8256
- KCNN3 in astrocytes, braak-0.34 (p 0.378) → +0.00 (p 1.000)receipt 8255
Swarm cases
receipt 8256: KCNN3 in dopamine neurons, braak
- power
- full sample -0.39 (p 0.107, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.40 (p 0.099, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.69 (p 0.0014, n 18). not the mix.
- skeptic
- leave-one-out range -0.52 to -0.31, sign flips 0; without severely affected donors -0.39 (p 0.107, n 18). fragile.
- cell type
- strongest in oligodendrocytes: -0.61 (p 0.0069, n 18) vs -0.39 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for KCNN3 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up KCNN3 · oligodendrocytes · braak: substantia nigra, an independent cohort (already registered)
receipt 8255: KCNN3 in astrocytes, braak
- power
- full sample -0.19 (p 0.439, n 18), 95% CI -0.61 to +0.30. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.19 (p 0.455, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.20 (p 0.418, n 18). could be the mix.
- skeptic
- leave-one-out range -0.34 to -0.10, sign flips 0; without severely affected donors -0.19 (p 0.439, n 18). fragile.
- cell type
- strongest in oligodendrocytes: -0.61 (p 0.0069, n 18) vs -0.19 in astrocytes. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for KCNN3 in astrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up KCNN3 · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.75 p 0.0077 (needs p < 2.6e-4)
Receipts
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