Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (adrenal cortex cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: enflurane, sevoflurane, desflurane +4 | 1.00 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 9768
Sealed predictions
- KCNK3 in dopamine neurons, braak-0.42 (p 0.258) → +0.00 (p 1.000)receipt 9775
Swarm cases
receipt 9775: KCNK3 in dopamine neurons, braak
- power
- full sample -0.26 (p 0.300, n 18), 95% CI -0.65 to +0.24. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.25 (p 0.315, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.46 (p 0.052, n 18). could be the mix.
- skeptic
- leave-one-out range -0.41 to -0.17, sign flips 0; without severely affected donors -0.26 (p 0.300, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for KCNK3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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