parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.04 (overall 0.02)	0.04
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in myonuclei	0.75
chemistry Open Targets	hard to drug	0.40
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 7408

KBTBD12 in dopamine neurons, braak+0.23 (p 0.555) → -0.63 (p 0.069)receipt 7417
KBTBD12 in microglia, braak-0.29 (p 0.457) → -0.02 (p 0.965)receipt 7416

receipt 7417: KBTBD12 in dopamine neurons, braak

power: full sample -0.22 (p 0.384, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.31 (p 0.207, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.42 (p 0.084, n 18). could be the mix.
skeptic: leave-one-out range -0.37 to -0.12, sign flips 0; without severely affected donors -0.22 (p 0.384, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for KBTBD12 in dopamine neurons.

case closed: nothing better to follow up.

receipt 7416: KBTBD12 in microglia, braak

power: full sample -0.14 (p 0.573, n 18), 95% CI -0.57 to +0.35. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.21 (p 0.413, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.08 (p 0.741, n 18). could be the mix.
skeptic: leave-one-out range -0.29 to -0.09, sign flips 0; without severely affected donors -0.14 (p 0.573, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for KBTBD12 in microglia.

case closed: nothing better to follow up.

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