Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.20 (overall 0.50) | 0.20 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 8 Parkinson's papers of 204 | 0.71 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 0241
Sealed predictions
- KAT8 in dopamine neurons, braak+0.08 (p 0.838) → -0.29 (p 0.445)receipt 0248
Swarm cases
receipt 0248: KAT8 in dopamine neurons, braak
- power
- full sample -0.15 (p 0.555, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.15 (p 0.555, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.16 (p 0.515, n 18). could be the mix.
- skeptic
- leave-one-out range -0.32 to -0.06, sign flips 0; without severely affected donors -0.15 (p 0.555, n 18). fragile.
- cell type
- strongest in microglia: +0.62 (p 0.0057, n 18) vs -0.15 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for KAT8 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up KAT8 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.20 p 0.477 (needs p < 0.0019)
Receipts
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