Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in lymphatic endothelial cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 109 | 0.91 |
| pathways Reactome | 8 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 5591
Sealed predictions
- KALRN in dopamine neurons, braak-0.03 (p 0.946) → +0.00 (p 1.000)receipt 5598
Swarm cases
receipt 5598: KALRN in dopamine neurons, braak
- power
- full sample -0.02 (p 0.942, n 18), 95% CI -0.48 to +0.45. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.04 (p 0.874, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.36 (p 0.137, n 18). could be the mix.
- skeptic
- leave-one-out range -0.14 to +0.11, sign flips 4; without severely affected donors -0.02 (p 0.942, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for KALRN in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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