Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.34 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 5 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 0977
Sealed predictions
- ITGB4 in dopamine neurons, braak-0.50 (p 0.175) → -0.50 (p 0.172)receipt 0984
Swarm cases
receipt 0984: ITGB4 in dopamine neurons, braak
- power
- full sample -0.62 (p 0.0062, n 18), 95% CI -0.84 to -0.21. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.64 (p 0.0040, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.70 (p 0.0012, n 18). not the mix.
- skeptic
- leave-one-out range -0.75 to -0.57, sign flips 0; without severely affected donors -0.62 (p 0.0062, n 18). robust.
- cell type
- strongest in microglia: -0.67 (p 0.0022, n 18) vs -0.62 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ITGB4 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up ITGB4 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.65 p 0.021 (needs p < 0.0013)
Receipts
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