Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 260 | 0.91 |
| pathways Reactome | 6 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8301
Sealed predictions
- ITGA1 in dopamine neurons, braak+0.37 (p 0.334) → +0.72 (p 0.030)receipt 8308
Swarm cases
receipt 8308: ITGA1 in dopamine neurons, braak
- power
- full sample +0.44 (p 0.069, n 18), 95% CI -0.04 to +0.75. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.53 (p 0.025, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.50 (p 0.033, n 18). not the mix.
- skeptic
- leave-one-out range +0.35 to +0.56, sign flips 0; without severely affected donors +0.44 (p 0.069, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ITGA1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts