parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.03 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in pdcs	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	5 Parkinson's papers of 1,290	0.76
pathways Reactome	3 pathways; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 6317

receipt 6327: IRF8 in dopamine neurons, braak

power: full sample -0.36 (p 0.148, n 18), 95% CI -0.71 to +0.13. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.40 (p 0.103, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.43 (p 0.072, n 18). could be the mix.
skeptic: leave-one-out range -0.45 to -0.27, sign flips 0; without severely affected donors -0.36 (p 0.148, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for IRF8 in dopamine neurons.

case closed: nothing better to follow up.

receipt 6326: IRF8 in microglia, braak

power: full sample +0.38 (p 0.123, n 18), 95% CI -0.11 to +0.72. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.43 (p 0.074, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.56 (p 0.017, n 18). not the mix.
skeptic: leave-one-out range +0.29 to +0.52, sign flips 0; without severely affected donors +0.38 (p 0.123, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for IRF8 in microglia.

case closed: nothing better to follow up.

loading the receipts