Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 8 Parkinson's papers of 2,450 | 0.71 |
| pathways Reactome | 9 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 3142
Sealed predictions
- IRF7 in dopamine neurons, braak-0.45 (p 0.222) → -0.82 (p 0.007)receipt 3148
Swarm cases
receipt 3148: IRF7 in dopamine neurons, braak
- power
- full sample -0.52 (p 0.028, n 18), 95% CI -0.79 to -0.07. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.49 (p 0.037, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.62 (p 0.0060, n 18). not the mix.
- skeptic
- leave-one-out range -0.66 to -0.45, sign flips 0; without severely affected donors -0.52 (p 0.028, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IRF7 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts