Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

INS

insulin

translation score 0.40, read 2026-10-19; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.10 from other evidence0.00
cell type
Human Protein Atlas
cell type enriched outside the brain (pancreatic islet cells)0.10
chemistry
Open Targets
a small-molecule pocket0.60
trials
ClinicalTrials.gov
60 Parkinson's trials, 2 stopped0.97
literature
PubMed
82 Parkinson's papers of 17,8090.42
pathways
Reactome
14 pathways; mostly vesicle traffic1.00

No case: the score is under the bar. Receipt 2567

Sealed predictions

  1. INS in dopamine neurons, braakn/a → n/areceipt 2574

Swarm cases

receipt 2574: INS in dopamine neurons, braak

cell type
INS is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for INS in dopamine neurons.

case closed: nothing better to follow up.

Receipts

loading the receipts