Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | not detected in single-cell data | 0.00 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 7 Parkinson's papers of 8,645 | 0.73 |
| pathways Reactome | 4 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 3389
Sealed predictions
- IL3 in dopamine neurons, braak+0.07 (p 0.855) → -0.38 (p 0.311)receipt 3398
Swarm cases
receipt 3398: IL3 in dopamine neurons, braak
- power
- full sample -0.28 (p 0.269, n 18), 95% CI -0.66 to +0.22. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.35 (p 0.159, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.55 (p 0.017, n 18). not the mix.
- skeptic
- leave-one-out range -0.41 to -0.19, sign flips 0; without severely affected donors -0.28 (p 0.269, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IL3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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