Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (early spermatids) | 0.10 |
| chemistry Open Targets | a small-molecule pocket: nnc0114-0006 | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 7 Parkinson's papers of 4,484 | 0.73 |
| pathways Reactome | 2 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 5357
Sealed predictions
- IL21 in dopamine neurons, braak+0.23 (p 0.549) → +0.61 (p 0.078)receipt 5364
Swarm cases
receipt 5364: IL21 in dopamine neurons, braak
- power
- full sample +0.34 (p 0.161, n 18), 95% CI -0.15 to +0.70. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.36 (p 0.145, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.32 (p 0.194, n 18). could be the mix.
- skeptic
- leave-one-out range +0.25 to +0.53, sign flips 0; without severely affected donors +0.34 (p 0.161, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IL21 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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