Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (neutrophils) | 0.10 |
| chemistry Open Targets | reachable by antibody: iboctadekin | 0.45 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 1 Parkinson's papers of 176 | 0.91 |
| pathways Reactome | 1 pathway; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 9900
Sealed predictions
- IL18RAP in dopamine neurons, braak+0.70 (p 0.034) → +0.49 (p 0.177)receipt 9907
Swarm cases
receipt 9907: IL18RAP in dopamine neurons, braak
- power
- full sample +0.55 (p 0.017, n 18), 95% CI +0.12 to +0.81. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.55 (p 0.018, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.55 (p 0.018, n 18). not the mix.
- skeptic
- leave-one-out range +0.50 to +0.76, sign flips 0; without severely affected donors +0.55 (p 0.017, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IL18RAP in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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