Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 301 | 0.91 |
| pathways Reactome | 32 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 6339
Sealed predictions
- IKBKG in dopamine neurons, braak-0.56 (p 0.116) → -0.44 (p 0.239)receipt 6346
Swarm cases
receipt 6346: IKBKG in dopamine neurons, braak
- power
- full sample -0.47 (p 0.051, n 18), 95% CI -0.77 to +0.00. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.51 (p 0.032, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.64 (p 0.0045, n 18). not the mix.
- skeptic
- leave-one-out range -0.63 to -0.40, sign flips 0; without severely affected donors -0.47 (p 0.051, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IKBKG in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts