Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

IGHM

immunoglobulin heavy constant mu

translation score 0.45, read 2026-10-26; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas
group enriched outside the brain (plasma cells)0.10
chemistry
Open Targets
reachable by antibody0.45
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
3 Parkinson's papers of 2610.82
pathways
Reactome
5 pathways; mostly immune signalling0.90

No case: the score is under the bar. Receipt 10692

Sealed predictions

  1. IGHM in dopamine neurons, braakn/a → n/areceipt 10699

Swarm cases

receipt 10699: IGHM in dopamine neurons, braak

cell type
IGHM is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IGHM in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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