parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.03 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in neutrophils	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	1 Parkinson's trial, 0 stopped	1.00
literature PubMed	1 Parkinson's papers of 644	0.91
pathways Reactome	2 pathways; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 6969

receipt 6977: IFI16 in dopamine neurons, braak

power: full sample +0.03 (p 0.894, n 18), 95% CI -0.44 to +0.49. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.00 (p 0.990, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.06 (p 0.814, n 18). could be the mix.
skeptic: leave-one-out range -0.07 to +0.20, sign flips 5; without severely affected donors +0.03 (p 0.894, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for IFI16 in dopamine neurons.

case closed: nothing better to follow up.

receipt 6976: IFI16 in microglia, braak

power: full sample +0.04 (p 0.867, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.07 (p 0.787, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.07 (p 0.774, n 18). could be the mix.
skeptic: leave-one-out range -0.05 to +0.20, sign flips 5; without severely affected donors +0.04 (p 0.867, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for IFI16 in microglia.

case closed: nothing better to follow up.

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