Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: ds-1001b, bay1436032, olutasidenib +5 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 6,240 | 0.79 |
| pathways Reactome | 5 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 6389
Sealed predictions
- IDH1 in dopamine neurons, braak+0.11 (p 0.778) → -0.29 (p 0.457)receipt 6396
Swarm cases
receipt 6396: IDH1 in dopamine neurons, braak
- power
- full sample -0.20 (p 0.429, n 18), 95% CI -0.61 to +0.30. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.16 (p 0.532, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.14 (p 0.579, n 18). could be the mix.
- skeptic
- leave-one-out range -0.31 to -0.10, sign flips 0; without severely affected donors -0.20 (p 0.429, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IDH1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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