Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.55 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (choroid plexus epithelial cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: fenfluramine hydrochloride, chlorprothixene, lorcaserin +41 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 10 Parkinson's papers of 437 | 0.69 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 11460
Earlier readings: 2026-10-26 0.41; 2026-10-25 0.41; 2026-10-24 0.41; 2026-10-23 0.41.
Sealed predictions
- HTR2C in dopamine neurons, braak+0.30 (p 0.428) → +0.50 (p 0.168)receipt 0586
- HTR2C in dopamine neurons, braak-0.02 (p 0.919) → -0.35 (p 0.024)receipt 0128
- HTR2C in dopamine neurons, resilience-0.40 (p 1.000) → +0.15 (p 0.539)receipt 0129
Swarm cases
receipt 0586: HTR2C in dopamine neurons, braak
- power
- full sample +0.32 (p 0.198, n 18), 95% CI -0.17 to +0.68. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.51 (p 0.031, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.50 (p 0.036, n 18). not the mix.
- skeptic
- leave-one-out range +0.22 to +0.48, sign flips 0; without severely affected donors +0.32 (p 0.198, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HTR2C in dopamine neurons.
case closed: nothing better to follow up.
receipt 0129: HTR2C in dopamine neurons, resilience
- power
- full sample +0.05 (p 0.801, n 55), 95% CI -0.22 to +0.31. the interval is wide: not enough donors to tell.
- confounder
- adjusted for age, sex and PMI: +0.01 (p 0.950, n 55). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.12 (p 0.542); controlling for it: -0.01 (p 0.966, n 55). could be the mix.
- skeptic
- leave-one-out range -0.01 to +0.15, sign flips 3; without severely affected donors +0.06 (p 0.748, n 46). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "differs in resilient donors (Lewy pathology, no parkinsonism)" for HTR2C in dopamine neurons.
case closed: nothing better to follow up.
receipt 0128: HTR2C in dopamine neurons, braak
- power
- full sample -0.18 (p 0.097, n 84), 95% CI -0.38 to +0.03. the interval sits on zero: probably nothing there.
- confounder
- adjusted for age, sex and PMI: -0.17 (p 0.112, n 84). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis -0.72 (p 1.8e-14); controlling for it: -0.10 (p 0.367, n 84). could be the mix.
- skeptic
- leave-one-out range -0.22 to -0.16, sign flips 0; without severely affected donors -0.21 (p 0.074, n 75). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HTR2C in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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