Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.41 from other evidence | 0.00 |
| cell type Human Protein Atlas | not detected in single-cell data | 0.00 |
| chemistry Open Targets | compounds already reach it: befiradol, dexfenfluramine, gepirone hydrochloride +32 | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 5 Parkinson's papers of 556 | 0.76 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 0615
Sealed predictions
- HTR1A in dopamine neurons, braak-0.24 (p 0.533) → -0.27 (p 0.489)receipt 0621
Swarm cases
receipt 0621: HTR1A in dopamine neurons, braak
- power
- full sample -0.27 (p 0.285, n 18), 95% CI -0.65 to +0.23. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.21 (p 0.393, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.03 (p 0.922, n 18). could be the mix.
- skeptic
- leave-one-out range -0.45 to -0.17, sign flips 0; without severely affected donors -0.27 (p 0.285, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HTR1A in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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