parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in renal connecting tubule cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	76 Parkinson's papers of 3,300	0.43
pathways Reactome	6 pathways; mostly mitochondrial quality control	1.00

No case: the score is under the bar. Receipt 7565

receipt 7573: HSF1 in dopamine neurons, braak

power: full sample +0.08 (p 0.761, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.08 (p 0.761, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.09 (p 0.709, n 18). could be the mix.
skeptic: leave-one-out range -0.04 to +0.22, sign flips 1; without severely affected donors +0.08 (p 0.761, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for HSF1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 7572: HSF1 in microglia, braak

power: full sample +0.19 (p 0.455, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.17 (p 0.509, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.18 (p 0.487, n 18). could be the mix.
skeptic: leave-one-out range +0.07 to +0.28, sign flips 0; without severely affected donors +0.19 (p 0.455, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for HSF1 in microglia.

case closed: nothing better to follow up.

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