Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: salirasib | 0.90 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 8 Parkinson's papers of 6,211 | 0.71 |
| pathways Reactome | 68 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 5789
Sealed predictions
- HRAS in dopamine neurons, braak+0.35 (p 0.349) → -0.17 (p 0.663)receipt 5796
Swarm cases
receipt 5796: HRAS in dopamine neurons, braak
- power
- full sample +0.05 (p 0.854, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.09 (p 0.735, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.03 (p 0.894, n 18). could be the mix.
- skeptic
- leave-one-out range -0.05 to +0.21, sign flips 2; without severely affected donors +0.05 (p 0.854, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HRAS in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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