Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.04 (overall 0.05) | 0.04 |
| cell type Human Protein Atlas | group enriched outside the brain (mast cells) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 5 Parkinson's papers of 254 | 0.76 |
| pathways Reactome | 2 pathways; mostly iron and oxidative stress | 0.80 |
No case: the score is under the bar. Receipt 5132
Sealed predictions
- HPGDS in dopamine neurons, braak+0.43 (p 0.251) → +0.10 (p 0.807)receipt 5139
Swarm cases
receipt 5139: HPGDS in dopamine neurons, braak
- power
- full sample +0.18 (p 0.471, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.20 (p 0.434, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.18 (p 0.487, n 18). could be the mix.
- skeptic
- leave-one-out range +0.08 to +0.26, sign flips 0; without severely affected donors +0.18 (p 0.471, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HPGDS in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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