Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 2,006 | 0.82 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6576
Sealed predictions
- HMGA2 in dopamine neurons, braak-0.03 (p 0.944) → +0.56 (p 0.114)receipt 6584
Swarm cases
receipt 6584: HMGA2 in dopamine neurons, braak
- power
- full sample +0.46 (p 0.052, n 18), 95% CI -0.00 to +0.77. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.41 (p 0.093, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.47 (p 0.049, n 18). not the mix.
- skeptic
- leave-one-out range +0.39 to +0.67, sign flips 0; without severely affected donors +0.46 (p 0.052, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HMGA2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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