Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 7 Parkinson's trials, 1 stopped | 0.89 |
| literature PubMed | 8 Parkinson's papers of 12,817 | 0.71 |
| pathways Reactome | 9 pathways; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 10293
Sealed predictions
- HLA-A in dopamine neurons, braak-0.30 (p 0.428) → -0.54 (p 0.130)receipt 10300
Swarm cases
receipt 10300: HLA-A in dopamine neurons, braak
- power
- full sample -0.14 (p 0.579, n 18), 95% CI -0.57 to +0.35. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.18 (p 0.471, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.17 (p 0.493, n 18). could be the mix.
- skeptic
- leave-one-out range -0.24 to -0.02, sign flips 0; without severely affected donors -0.14 (p 0.579, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HLA-A in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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