Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.81 (overall 0.50) | 0.81 |
| cell type Human Protein Atlas | Human Protein Atlas did not answer (Human Protein Atlas: The operation was aborted due to timeout) | 0.00 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 18 Parkinson's papers of 125 | 0.61 |
| pathways Reactome | 2 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 0226
Sealed predictions
- HIP1R in dopamine neurons, braak-0.53 (p 0.145) → -0.55 (p 0.122)receipt 0232
Swarm cases
receipt 0232: HIP1R in dopamine neurons, braak
- power
- full sample -0.51 (p 0.029, n 18), 95% CI -0.79 to -0.06. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.53 (p 0.025, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.52 (p 0.027, n 18). not the mix.
- skeptic
- leave-one-out range -0.68 to -0.44, sign flips 0; without severely affected donors -0.51 (p 0.029, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HIP1R in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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