Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 53 Parkinson's trials, 4 stopped | 0.94 |
| literature PubMed | 46 Parkinson's papers of 4,124 | 0.49 |
| pathways Reactome | 1 pathway; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 4445
Sealed predictions
- HFE in dopamine neurons, braak-0.32 (p 0.400) → -0.79 (p 0.011)receipt 4453
Swarm cases
receipt 4453: HFE in dopamine neurons, braak
- power
- full sample -0.50 (p 0.035, n 18), 95% CI -0.78 to -0.04. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.54 (p 0.021, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.57 (p 0.013, n 18). not the mix.
- skeptic
- leave-one-out range -0.64 to -0.43, sign flips 0; without severely affected donors -0.50 (p 0.035, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HFE in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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