Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.10 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: cudc-101, panobinostat, belinostat +11 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 68 Parkinson's papers of 3,013 | 0.44 |
| pathways Reactome | 12 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 2543
Sealed predictions
- HDAC6 in dopamine neurons, braak+0.33 (p 0.388) → -0.57 (p 0.111)receipt 2550
Swarm cases
receipt 2550: HDAC6 in dopamine neurons, braak
- power
- full sample -0.12 (p 0.646, n 18), 95% CI -0.55 to +0.37. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.25 (p 0.319, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.40 (p 0.101, n 18). could be the mix.
- skeptic
- leave-one-out range -0.26 to +0.01, sign flips 2; without severely affected donors -0.12 (p 0.646, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HDAC6 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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