Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: belinostat, fimepinostat, mocetinostat +11 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 19 Parkinson's papers of 5,137 | 0.61 |
| pathways Reactome | 42 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 7117
Sealed predictions
- HDAC1 in dopamine neurons, braak+0.26 (p 0.504) → +0.02 (p 0.964)receipt 7124
Swarm cases
receipt 7124: HDAC1 in dopamine neurons, braak
- power
- full sample +0.22 (p 0.389, n 18), 95% CI -0.28 to +0.62. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.23 (p 0.369, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.21 (p 0.398, n 18). could be the mix.
- skeptic
- leave-one-out range +0.12 to +0.37, sign flips 0; without severely affected donors +0.22 (p 0.389, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HDAC1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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