Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (epididymal basal cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: sch-900271 | 0.90 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 7 Parkinson's papers of 136 | 0.73 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3446
Sealed predictions
- HCAR2 in dopamine neurons, braak-0.23 (p 0.554) → -0.30 (p 0.436)receipt 3453
Swarm cases
receipt 3453: HCAR2 in dopamine neurons, braak
- power
- full sample -0.23 (p 0.350, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.22 (p 0.374, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.27 (p 0.277, n 18). could be the mix.
- skeptic
- leave-one-out range -0.35 to -0.14, sign flips 0; without severely affected donors -0.23 (p 0.350, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HCAR2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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