Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug: voxelotor, efaproxiral | 0.00 |
| trials ClinicalTrials.gov | 3 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 3 Parkinson's papers of 2,264 | 0.82 |
| pathways Reactome | 6 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8963
Sealed predictions
- HBA1 in dopamine neurons, braak+0.26 (p 0.493) → -0.15 (p 0.702)receipt 8971
Swarm cases
receipt 8971: HBA1 in dopamine neurons, braak
- power
- full sample +0.03 (p 0.908, n 18), 95% CI -0.44 to +0.49. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.09 (p 0.735, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.15 (p 0.561, n 18). could be the mix.
- skeptic
- leave-one-out range -0.07 to +0.15, sign flips 5; without severely affected donors +0.03 (p 0.908, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HBA1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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