Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

H1-2

H1.2 linker histone, cluster member

translation score 0.38, read 2026-10-26; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas
expressed broadly, no clear home in brain cells0.40
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
10 Parkinson's trials, 2 stopped0.84
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
2 pathways; mostly other0.30

No case: the score is under the bar. Receipt 11202

Sealed predictions

  1. H1-2 in dopamine neurons, braakn/a → n/areceipt 11208

Swarm cases

receipt 11208: H1-2 in dopamine neurons, braak

cell type
H1-2 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for H1-2 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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