Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: carmustine, oxiglutatione | 1.00 |
| trials ClinicalTrials.gov | 15 Parkinson's trials, 1 stopped | 0.95 |
| literature PubMed | 11 Parkinson's papers of 2,642 | 0.67 |
| pathways Reactome | 5 pathways; mostly iron and oxidative stress | 0.80 |
No case: the score is under the bar. Receipt 3285
Sealed predictions
- GSR in dopamine neurons, braak+0.30 (p 0.428) → -0.46 (p 0.209)receipt 3292
Swarm cases
receipt 3292: GSR in dopamine neurons, braak
- power
- full sample -0.13 (p 0.603, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.25 (p 0.310, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.31 (p 0.218, n 18). could be the mix.
- skeptic
- leave-one-out range -0.24 to -0.02, sign flips 0; without severely affected donors -0.13 (p 0.603, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GSR in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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