Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.55 (overall 0.37) | 0.55 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 163 Parkinson's papers of 3,264 | 0.33 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 0825
Sealed predictions
- GRN in dopamine neurons, braak-0.78 (p 0.013) → +0.11 (p 0.787)receipt 0831
Swarm cases
receipt 0831: GRN in dopamine neurons, braak
- power
- full sample -0.33 (p 0.179, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.34 (p 0.173, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.33 (p 0.176, n 18). could be the mix.
- skeptic
- leave-one-out range -0.49 to -0.24, sign flips 0; without severely affected donors -0.33 (p 0.179, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GRN in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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