Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.26 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 21 Parkinson's papers of 259 | 0.59 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 1651
Sealed predictions
- GRK6 in dopamine neurons, braak+0.04 (p 0.910) → -0.53 (p 0.143)receipt 1658
Swarm cases
receipt 1658: GRK6 in dopamine neurons, braak
- power
- full sample -0.18 (p 0.471, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.25 (p 0.323, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.22 (p 0.379, n 18). could be the mix.
- skeptic
- leave-one-out range -0.29 to -0.07, sign flips 0; without severely affected donors -0.18 (p 0.471, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GRK6 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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