Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched in brain inhibitory neurons (13 nCPM) | 1.00 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 22 Parkinson's papers of 75 | 0.59 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 5688
Sealed predictions
- GPR6 in dopamine neurons, braak-0.04 (p 0.928) → +0.05 (p 0.893)receipt 5695
Swarm cases
receipt 5695: GPR6 in dopamine neurons, braak
- power
- full sample -0.13 (p 0.609, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.06 (p 0.807, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.44 (p 0.066, n 18). could be the mix.
- skeptic
- leave-one-out range -0.27 to -0.03, sign flips 0; without severely affected donors -0.13 (p 0.609, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GPR6 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts