Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in retinal horizontal cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 93 | 0.82 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 10455
Sealed predictions
- GPR158 in dopamine neurons, braak+0.36 (p 0.347) → +0.43 (p 0.253)receipt 10462
Swarm cases
receipt 10462: GPR158 in dopamine neurons, braak
- power
- full sample +0.45 (p 0.062, n 18), 95% CI -0.02 to +0.76. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.45 (p 0.062, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.52 (p 0.027, n 18). not the mix.
- skeptic
- leave-one-out range +0.38 to +0.67, sign flips 0; without severely affected donors +0.45 (p 0.062, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GPR158 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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