Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (platelets) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 29 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 11531
Sealed predictions
- GNG8 in dopamine neurons, braak+0.25 (p 0.517) → +0.24 (p 0.535)receipt 11537
Swarm cases
receipt 11537: GNG8 in dopamine neurons, braak
- power
- full sample +0.11 (p 0.674, n 18), 95% CI -0.38 to +0.55. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.13 (p 0.600, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.20 (p 0.418, n 18). could be the mix.
- skeptic
- leave-one-out range -0.00 to +0.20, sign flips 1; without severely affected donors +0.11 (p 0.674, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GNG8 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts