Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

GNG10

G protein subunit gamma 10

translation score 0.63, read 2026-10-26; 2 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced in microglia (26 nCPM)1.00
chemistry
Open Targets		reachable by antibody0.45
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		no papers tie it to Parkinson's yet1.00
pathways
Reactome		29 pathways; mostly dopamine synapse1.00
proposal for GNG10, translation score 0.63

Knock down and overexpress GNG10 in microglia; measure evoked dopamine release and dopamine transporter uptake and uptake and clearance of α-synuclein fibrils and NLRP3 inflammasome activation (IL-1β release).

Cell type
microglia
Direction
Both arms: public data does not say which way helps.
Molecular readout
evoked dopamine release and dopamine transporter uptake
Functional readout
uptake and clearance of α-synuclein fibrils and NLRP3 inflammasome activation (IL-1β release)
Rule-out
If neither arm moves evoked dopamine release by 20% or more against non-targeting and empty-vector controls, across three independent differentiations, the hypothesis is wrong.
Lab request
CRISPRi knockdown and lentiviral overexpression of GNG10 in iPSC-derived microglia (iMGL); n = 3 differentiations; readouts: evoked dopamine release and dopamine transporter uptake; uptake and clearance of α-synuclein fibrils and NLRP3 inflammasome activation (IL-1β release). Controls: non-targeting guide, empty vector. About 8 to 10 weeks, most of it differentiation.

Sealed predictions

  1. GNG10 in dopamine neurons, braakn/a → n/areceipt 11114
  2. GNG10 in microglia, braakn/a → n/areceipt 11113

Swarm cases

receipt 11114: GNG10 in dopamine neurons, braak

cell type
GNG10 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GNG10 in dopamine neurons.

case closed: nothing better to follow up.

receipt 11113: GNG10 in microglia, braak

cell type
GNG10 is not measured in microglia; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GNG10 in microglia.

case closed: nothing better to follow up.

Receipts

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