Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 39 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 19 Parkinson's papers of 855 | 0.61 |
| pathways Reactome | 2 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 8160
Sealed predictions
- GNE in dopamine neurons, braak-0.53 (p 0.146) → -0.35 (p 0.362)receipt 8198
Swarm cases
receipt 8198: GNE in dopamine neurons, braak
- power
- full sample -0.36 (p 0.145, n 18), 95% CI -0.71 to +0.13. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.36 (p 0.140, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.33 (p 0.179, n 18). could be the mix.
- skeptic
- leave-one-out range -0.49 to -0.28, sign flips 0; without severely affected donors -0.36 (p 0.145, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GNE in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts